abstract：BACKGROUND:There is considerable heterogeneity in the rate of lung function decline in chronic obstructive pulmonary disease (COPD), the determinants of which are largely unknown. Observational studies in COPD indicate that low body mass index (BMI) is associated with worse outcomes, and overweight/obesity has a protec...

journal_title：Respiratory research

authors： Sun Y,Milne S,Jaw JE,Yang CX,Xu F,Li X,Obeidat M,Sin DD

更新日期：2019-10-29 00:00:00

abstract：BACKGROUND:The differential diagnosis of tuberculous pleural effusion (TPE) is challenging. In recent years, artificial intelligence (AI) machine learning algorithms have started being used to an increasing extent in disease diagnosis due to the high level of efficiency, objectivity, and accuracy that they offer. METH...

journal_title：Respiratory research

authors： Ren Z,Hu Y,Xu L

更新日期：2019-10-16 00:00:00

abstract：BACKGROUND:The prevalence of pneumocystis pneumonia (PCP) and associated hypoxic respiratory failure is increasing in human immunodeficiency virus (HIV)-negative patients. However, no prior studies have evaluated the effect of early anti-PCP treatment on clinical outcomes in HIV-negative patient with severe PCP. Theref...

journal_title：Respiratory research

authors： Ko RE,Na SJ,Huh K,Suh GY,Jeon K

更新日期：2019-09-26 00:00:00

abstract：BACKGROUND:Initial combination therapy with ambrisentan and tadalafil reduced the risk of clinical failure events for treatment-naïve participants with pulmonary arterial hypertension (PAH) as compared to monotherapy. Previous studies in PAH have demonstrated greater treatment benefits in more symptomatic participants....

journal_title：Respiratory research

authors： White RJ,Vonk-Noordegraaf A,Rosenkranz S,Oudiz RJ,McLaughlin VV,Hoeper MM,Grünig E,Ghofrani HA,Chakinala MM,Barberà JA,Blair C,Langley J,Frost AE

更新日期：2019-09-12 00:00:00

abstract：BACKGROUND:It is unclear whether the responses of refractory and common Mycoplasma pneumoniae (MP) pneumonia to macrolides differ. Hence, this study aimed to identify biomarkers that may be used to distinguish refractory and common pneumonias caused by MP in children at hospital admission. METHODS:The study included 1...

journal_title：Respiratory research

authors： Choi YJ,Jeon JH,Oh JW

更新日期：2019-08-23 00:00:00

abstract：BACKGROUND:An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. A more systematic understanding would help to improve the design and interpretation of COPD trials. ...

journal_title：Respiratory research

authors： Andreas S,Röver C,Heinz J,Straube S,Watz H,Friede T

更新日期：2019-08-16 00:00:00

abstract：BACKGROUND:Generally, structural destruction of lung parenchyma, such as pulmonary emphysema, is considered to be related to the low diagnostic yields and high complication rates of lung biopsies of peripheral lung lesions. Currently, little is known about the clinical outcomes of using endobronchial ultrasound with a ...

journal_title：Respiratory research

authors： Lee KM,Lee G,Kim A,Mok J,Lee JW,Jeong YJ,Jo EJ,Kim MH,Lee K,Kim KU,Park HK,Lee MK,Eom JS

更新日期：2019-08-06 00:00:00

abstract：:There is increasing focus on understanding the nature of chronic obstructive pulmonary disease (COPD) during the earlier stages. Mild COPD (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 1 or the now-withdrawn GOLD stage 0) represents an early stage of COPD that may progress to more severe disease...

journal_title：Respiratory research

authors： Singh D,D'Urzo AD,Donohue JF,Kerwin EM

更新日期：2019-07-08 00:00:00

abstract：BACKGROUND:Lung cancer is one of the leading cause of cancer-related death in the world. Recently, many clinical researches have reported that COL6A3 had strong role in many diseases. The aim of this study was to evaluate the association between single nucleotide polymorphisms (SNPs) in COL6A3 and lung cancer susceptib...

journal_title：Respiratory research

authors： Duan Y,Liu G,Sun Y,Wu J,Xiong Z,Jin T,Chen M

更新日期：2019-07-08 00:00:00

abstract：BACKGROUND:Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its anti-microbial activity or other pharmacological actions. We have shown that Azm affects the integrity ...

journal_title：Respiratory research

authors： Arason AJ,Joelsson JP,Valdimarsdottir B,Sigurdsson S,Gudjonsson A,Halldorsson S,Johannsson F,Rolfsson O,Lehmann F,Ingthorsson S,Cherek P,Gudmundsson GH,Gardarsson FR,Page CP,Baldursson O,Gudjonsson T,Kricker JA

更新日期：2019-06-24 00:00:00

abstract：BACKGROUND:A multitude of epidemiological studies have shown that ambient fine particulate matter 2.5 (diameter < 2.5um; PM2.5) was associated with increased morbidity and mortality of chronic obstructive pulmonary disease (COPD). However, the underlying associated mechanisms have not yet been elucidated. We conducted ...

journal_title：Respiratory research

authors： Zhao J,Li M,Wang Z,Chen J,Zhao J,Xu Y,Wei X,Wang J,Xie J

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:Asthma is a heterogeneous chronic airway disease, which may be classified into different phenotypes. YKL-40 is a chitin-binding glycoprotein with unclear functions, but its expression is associated with inflammation and tissue remodeling. However, few studies have explored whether YKL-40 is associated with i...

journal_title：Respiratory research

authors： Liu L,Zhang X,Liu Y,Zhang L,Zheng J,Wang J,Hansbro PM,Wang L,Wang G,Hsu AC

更新日期：2019-05-22 00:00:00

abstract：:Pre-bronchodilator lung function including forced vital capacity (FVC), forced expiratory flow in 1 second (FEV1), their ratio (FEV1/FVC), and forced expiratory flow 25-75% (FEF25-75) measured at age 10, 18, and 26 years in the Isle of Wight birth cohort was analyzed for developmental patterns (trajectories). Early li...

journal_title：Respiratory research

authors： Karmaus W,Mukherjee N,Janjanam VD,Chen S,Zhang H,Roberts G,Kurukulaaratchy RJ,Arshad H

更新日期：2019-05-22 00:00:00

abstract：BACKGROUND:The burden of symptoms and risk of exacerbations are the main drivers of the overall assessment of the Chronic Obstructive Pulmonary Disease (COPD) and the adequate treatment approaches per current Global Initiative for Chronic Obstructive Lung Disease (GOLD). Physical activity has emerged as both functional...

journal_title：Respiratory research

authors： Mihaltan F,Adir Y,Antczak A,Porpodis K,Radulovic V,Pires N,de Vries GJ,Horner A,De Bontridder S,Chen Y,Shavit A,Alecu S,Adamek L

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Although feelings of anxiety and depression are common in patients with chronic obstructive pulmonary disease (COPD), little is known about the estimates of their incidence in patients with asthma-COPD overlap (ACO), which has been described and acknowledged as a distinct clinical entity. We aimed to estimat...

journal_title：Respiratory research

authors： Kang HR,Hong SH,Ha SY,Kim TB,Lee EK

更新日期：2019-04-30 00:00:00

abstract：BACKGROUND:Quality of life (QoL) is profoundly impaired in patients with idiopathic pulmonary fibrosis (IPF). However, data is limited regarding the course of QoL. We therefore analysed longitudinal data from the German INSIGHTS-IPF registry. METHODS:Clinical status and QoL were assessed at enrollment and subsequently...

journal_title：Respiratory research

authors： Kreuter M,Swigris J,Pittrow D,Geier S,Klotsche J,Prasse A,Wirtz H,Koschel D,Andreas S,Claussen M,Grohé C,Wilkens H,Hagmeyer L,Skowasch D,Meyer JF,Kirschner J,Gläser S,Kahn N,Welte T,Neurohr C,Schwaiblmair M,Held

更新日期：2019-03-15 00:00:00

abstract：:A proportion of patients with certain types of interstitial lung disease (ILD), including chronic hypersensitivity pneumonitis and ILDs associated with autoimmune diseases, develop a progressive fibrosing phenotype that shows similarities in clinical course to idiopathic pulmonary fibrosis. Irrespective of the clinica...

journal_title：Respiratory research

authors： Kolb M,Vašáková M

更新日期：2019-03-14 00:00:00

abstract：:Small airways disease (SAD) is a cardinal feature of chronic obstructive pulmonary disease (COPD) first recognized in the nineteenth century. The diverse histopathological features associated with SAD underpin the heterogeneous nature of COPD. Our understanding of the key molecular mechanisms which drive the pathologi...

journal_title：Respiratory research

authors： Higham A,Quinn AM,Cançado JED,Singh D

更新日期：2019-03-04 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a rare disease with a median survival of 3-5 years after diagnosis with limited treatment options. The aim of this study is to assess the psychometric characteristics of the Short Form 36 Health Status Questionnaire (SF-36) in IPF and to provide disease specific minimal...

journal_title：Respiratory research

authors： Witt S,Krauss E,Barbero MAN,Müller V,Bonniaud P,Vancheri C,Wells AU,Vasakova M,Pesci A,Klepetko W,Seeger W,Crestani B,Leidl R,Holle R,Schwarzkopf L,Guenther A

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea syndrome (OSAS) is a common disorder with significant morbidity and mortality. We aimed to evaluate the predictive accuracy of the Berlin questionnaire in patients with suspected OSAS undergoing PSG in the sleep laboratory setting against those going through the Embletta™ portable dia...

journal_title：Respiratory research

authors： Ng SS,Tam W,Chan TO,To KW,Ngai J,Chan KKP,Yip WH,Lo RL,Yiu K,Ko FW,Hui DS

更新日期：2019-02-22 00:00:00

abstract：:The diagnosis of depression, a frequent comorbidity of chronic obstructive pulmonary disease (COPD), is often supported by questionnaires, such as the Patient Health Questionnaire 9 (PHQ-9). It is unknown to which extent its single questions are affected by the clinical characteristics of COPD patients.We addressed th...

journal_title：Respiratory research

authors： von Siemens SM,Jörres RA,Behr J,Alter P,Lutter J,Lucke T,Söhler S,Welte T,Watz H,Vogelmeier CF,Trudzinski F,Rief W,Herbig B,Kahnert K,COSYCONET study group.

更新日期：2019-02-11 00:00:00

abstract：BACKGROUND:The acute respiratory distress syndrome (ARDS) is characterized by the acute onset of hypoxemia and bilateral lung infiltrates in response to an inciting event, and is associated with high morbidity and mortality. Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are at increased ...

journal_title：Respiratory research

authors： Englert JA,Cho MH,Lamb AE,Shumyatcher M,Barragan-Bradford D,Basil MC,Higuera A,Isabelle C,Vera MP,Dieffenbach PB,Fredenburgh LE,Kang JB,Bhatt AS,Antin JH,Ho VT,Soiffer RJ,Howrylak JA,Himes BE,Baron RM

更新日期：2019-01-21 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is a rare connective tissue disease with a heterogeneous clinical course. Interstitial lung disease (ILD) is a common manifestation of SSc and a leading cause of death. MAIN BODY:All patients newly diagnosed with SSc should receive a comprehensive clinical evaluation, including asse...

journal_title：Respiratory research

authors： Cottin V,Brown KK

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signalling by 9-cis retinoic acid, a vitamin A derivative. RXRs play key roles not only as homodimers but also as heterodimeric partners, e.g., for retinoic acid receptors, vitamin D receptors, and peroxisome prolif...

journal_title：Respiratory research

authors： Morichika D,Miyahara N,Fujii U,Taniguchi A,Oda N,Senoo S,Kataoka M,Tanimoto M,Kakuta H,Kiura K,Maeda Y,Kanehiro A

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:Growing evidences suggested that the Mycobacterium tuberculosis complex (MTBC) lineages can determine the clinical outcome of pulmonary and extra-pulmonary tuberculosis. However, limited data only available revealing such association of bacterial genotypes and clinical phenotypes from immigrant rich countrie...

journal_title：Respiratory research

authors： Varghese B,Enani M,Alrajhi A,Al Johani S,Albarak A,Althawadi S,Elkhizzi N,AlGhafli H,Shoukri M,Al-Hajoj S

更新日期：2018-12-27 00:00:00

abstract：: ...

journal_title：Respiratory research

authors：

更新日期：2018-12-20 00:00:00

abstract：BACKGROUND:Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with loss of lung function and poor outcomes for patients. However, there are limited data on the time course of changes in forced expiratory volume in 1 s (FEV1) preceding the first reported symptom and after the start of an exacer...

journal_title：Respiratory research

authors： Watz H,Tetzlaff K,Magnussen H,Mueller A,Rodriguez-Roisin R,Wouters EFM,Vogelmeier C,Calverley PMA

更新日期：2018-12-13 00:00:00

abstract：BACKGROUND:Host-associated microbial communities have important roles in tissue homeostasis and overall health. Severe perturbations can occur within these microbial communities during critical illness due to underlying diseases and clinical interventions, potentially influencing patient outcomes. We sought to profile ...

journal_title：Respiratory research

authors： Lamarche D,Johnstone J,Zytaruk N,Clarke F,Hand L,Loukov D,Szamosi JC,Rossi L,Schenck LP,Verschoor CP,McDonald E,Meade MO,Marshall JC,Bowdish DME,Karachi T,Heels-Ansdell D,Cook DJ,Surette MG,PROSPECT Investigators.,C

更新日期：2018-12-07 00:00:00

abstract：: ...

journal_title：Respiratory research

authors： Lotvall J,Panettieri RA Jr

更新日期：2018-11-26 00:00:00

abstract：BACKGROUND:Few longitudinal studies examine inflammation and lung function in asthma. We sought to determine the cytokines that reduce airflow, and the influence of respiratory viral infections on these relationships. METHODS:Children underwent home collections of nasal lavage during scheduled surveillance periods and...

journal_title：Respiratory research

authors： Lewis TC,Metitiri EE,Mentz GB,Ren X,Carpenter AR,Goldsmith AM,Wicklund KE,Eder BN,Comstock AT,Ricci JM,Brennan SR,Washington GL,Owens KB,Mukherjee B,Robins TG,Batterman SA,Hershenson MB,Community Action Against Asthma S

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:Work-place exposure to silica dust may lead to progressive lung inflammation culminating in the development of silicosis, an irreversible condition that can be complicated by onset of pulmonary hypertension (PH). The molecular mechanisms leading to the development of PH and lung fibrosis in response to silic...

journal_title：Respiratory research

authors： Zelko IN,Zhu J,Roman J

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:The identification of smoking-related lung disease in current and former smokers with normal FEV1 is complex, leading to debate regarding using a ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC) of less than 0.70 versus the predicted lower limit of normal (LLN) for diagnosis of ai...

journal_title：Respiratory research

authors： Pirozzi CS,Gu T,Quibrera PM,Carretta EE,Han MK,Murray S,Cooper CB,Tashkin DP,Kleerup EC,Barjaktarevic I,Hoffman EA,Martinez CH,Christenson SA,Hansel NN,Graham Barr R,Bleecker ER,Ortega VE,Martinez FJ,Kanner RE,Paine

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Lung inflammation in COPD is poorly controlled by inhaled corticosteroids (ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those patients candidates to receive ICS in COPD are needed. Recent data indicate that MUC1 cytoplasmic tail (CT) membrane mucin can mediate corticost...

journal_title：Respiratory research

authors： Milara J,Díaz-Platas L,Contreras S,Ribera P,Roger I,Ballester B,Montero P,Cogolludo Á,Morcillo E,Cortijo J

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is chronic fibrosing pneumonia with an unpredictable natural disease history. Functional respiratory imaging (FRI) has potential to better characterize this disease. The aim of this study was to identify FRI parameters, which predict FVC decline in patients with IPF. METH...

journal_title：Respiratory research

authors： Clukers J,Lanclus M,Mignot B,Van Holsbeke C,Roseman J,Porter S,Gorina E,Kouchakji E,Lipson KE,De Backer W,De Backer J

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Inhaled furosemide offers a potentially novel treatment for dyspnoea, which may reflect modulation of pulmonary stretch receptor feedback to the brain. Specificity of relief is unclear because different neural pathways may account for different components of clinical dyspnoea. Our objective was to evaluate i...

journal_title：Respiratory research

authors： Grogono JC,Butler C,Izadi H,Moosavi SH

更新日期：2018-09-20 00:00:00

abstract：BACKGROUND:Patients with severe uncontrolled asthma may receive oral corticosteroid (OCS) treatment regularly. The present study investigated the health care resource utilization and cost in regularly OCS treated Swedish asthma patients. METHODS:Primary care medical records data were linked to data from Swedish nation...

journal_title：Respiratory research

authors： Janson C,Lisspers K,Ställberg B,Johansson G,Telg G,Thuresson M,Nordahl Christensen H,Larsson K

更新日期：2018-09-03 00:00:00

abstract：BACKGROUND:Real-world evidence (RWE) can inform patient management decisions, but RWE studies are associated with limitations. Linkage of different RWE data types could address such limitations by enriching data and improving scientific quality. Using the example of chronic obstructive pulmonary disease (COPD) in Germa...

journal_title：Respiratory research

authors： Mueller S,Gottschalk F,Groth A,Meeraus W,Driessen M,Kohlmann T,Wilke T

更新日期：2018-08-30 00:00:00

abstract：BACKGROUND:The prevalence and incidence of sarcoidosis varies worldwide. We estimated the prevalence and incidence of sarcoidosis in Korea using nationwide claims data from the Korean Health Insurance Review and Assessment Service. METHODS:Cases of sarcoidosis were identified for any visit between 2007 to 2016 that li...

journal_title：Respiratory research

authors： Yoon HY,Kim HM,Kim YJ,Song JW

更新日期：2018-08-28 00:00:00

abstract：BACKGROUND:Acute respiratory distress syndrome (ARDS) is a severe form of lung injury characterized by damage to the epithelial barrier with subsequent pulmonary edema and hypoxic respiratory failure. ARDS is a significant medical problem in intensive care units with associated high care costs. There are many potential...

journal_title：Respiratory research

authors： Dolinay T,Aonbangkhen C,Zacharias W,Cantu E,Pogoriler J,Stablow A,Lawrence GG,Suzuki Y,Chenoweth DM,Morrisey E,Christie JD,Beers MF,Margulies SS

更新日期：2018-08-22 00:00:00

abstract：BACKGROUND:Alpha-1-Antitrypsin (AAT) deficiency (AATD) is a hereditary disorder that manifests primarily as pulmonary emphysema and liver cirrhosis. The clinically most relevant mutation causing AATD is a single nucleotide polymorphism Glu342Lys (Z-mutation). Despite the recommendation to test every COPD patient, the c...

journal_title：Respiratory research

authors： Greulich T,Rodríguez-Frias F,Belmonte I,Klemmer A,Vogelmeier CF,Miravitlles M

更新日期：2018-08-13 00:00:00